Free fatty acid receptor 4 in cardiac myocytes ameliorates ischemic cardiomyopathy.

Michael J ZhangSergey KarachenetsDylan J GybergSara PucciniChastity L HealySteven C WuGregory C ShearerTimothy D O'Connell

Published in: bioRxiv : the preprint server for biology (2024)

Our results demonstrate that Ffar4 in cardiac myocytes attenuates systolic dysfunction post-I/R, potentially by attenuating oxidative stress, preserving mitochondrial function, and modulation of cGMP signaling.

Keyphrases

oxidative stress
left ventricular
fatty acid
heart failure
ischemia reperfusion injury
blood pressure
nitric oxide
dna damage
mouse model
induced apoptosis
protein kinase
binding protein
blood brain barrier
cerebral ischemia
heat stress
heat shock protein
brain injury