Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy.

Birgit GrundJason V BakerSteven G DeeksJulian WolfsonDeborah WentworthAlessandro Cozzi-LepriCalvin J CohenAndrew PhillipsJens D LundgrenJames D Neatonnull null

Published in: PloS one (2016)

Both IL-6 and D-dimer are independently associated with serious non-AIDS conditions or death among HIV-positive adults with suppressed virus. This suggests that treatments that reduce IL-6 and D-dimer levels might substantially decrease morbidity and mortality in patients on suppressive ART. Clinical trials are needed to test this hypothesis.

Keyphrases

antiretroviral therapy
hiv positive
hiv infected
human immunodeficiency virus
hiv infected patients
hiv aids
clinical trial
men who have sex with men
end stage renal disease
ejection fraction
south africa
newly diagnosed
prognostic factors
randomized controlled trial
hepatitis c virus
patient reported
open label