Complement Profiles in Patients with Amyotrophic Lateral Sclerosis: A Prospective Observational Cohort Study.

Anne-Lene KjældgaardKatrine PilelyKarsten Skovgaard OlsenAnne Øberg LauritsenStephen Wørlich PedersenKirsten SvenstrupMerete KarlsborgHelle ThagesenMorten BlaabjergÁsta TheódórsdóttirElisabeth Gundtoft ElmoAnette Torvin MøllerNiels Anker PedersenNiels KirkegaardKirsten MøllerPeter Garred

Published in: Journal of inflammation research (2021)

ALS patients exhibit aberrant expression of selected mediators of the lectin complement pathway as well as increased activation of the terminal complement pathway, corroborating the notion that the complement system might be involved in the pathophysiology of ALS.

Keyphrases

amyotrophic lateral sclerosis
end stage renal disease
ejection fraction
newly diagnosed
poor prognosis
patient reported outcomes
long non coding rna