Interleukin-17A stimulation induces alterations in Microglial microRNA expression profiles.
Yukako IitaniRika MikiKenji ImaiKazuya FumaTakafumi UshidaSho TanoKosuke YoshidaAkira YokoiHiroaki KajiyamaTomomi KotaniPublished in: Pediatric research (2023)
Despite the growing evidence of interleukin (IL)-17A and microglia in the pathology of maternal immune activation (MIA), the downstream of IL-17A in microglia is not fully known. IL-17A altered microRNA profiles and upregulated the mmu-miR-206-3p expression in microglia. The mmu-miR-206-3p reduced autism spectrum disorder (ASD) related gene expressions, Hdac4 and Igf1. The Hdac4 expression was also reduced in the brain of MIA offspring. The hsa-miR-206 sequence is consistent with that of mmu-miR-206-3p. This study may provide clues to pathological mechanisms leading to predictions and interventions for ASD children born to mothers with IL-17A-related disorders.
Keyphrases
- autism spectrum disorder
- inflammatory response
- poor prognosis
- neuropathic pain
- attention deficit hyperactivity disorder
- intellectual disability
- long non coding rna
- binding protein
- cell proliferation
- young adults
- spinal cord
- type diabetes
- skeletal muscle
- dna methylation
- multiple sclerosis
- gene expression
- pregnant women
- brain injury
- cerebral ischemia
- amino acid
- working memory
- human serum albumin