Hepatocyte Stress Increases Expression of Yes-Associated Protein and Transcriptional Coactivator With PDZ-Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis.

Meghan MooringBrendan H FowlShelly Z C LumYe LiuKangning YaoSamir SofticRory KirchnerAaron BernsteinAatur D SinghiDaniel G JayC Ronald KahnFernando D CamargoDean Yimlamai

Published in: Hepatology (Baltimore, Md.) (2020)

Liver injury in mice and humans increases levels of YAP/TAZ/CYR61 in hepatocytes, thus attracting macrophages to the liver to promote inflammation and fibrosis.

Keyphrases

liver injury
drug induced
oxidative stress
poor prognosis
gene expression
transcription factor
high fat diet induced
liver fibrosis
dna binding
metabolic syndrome
adipose tissue
insulin resistance