Transcriptomic Analysis Reveals the MicroRNAs Responsible for Liver Regeneration Associated With Mortality in Alcohol-Associated Hepatitis.
Zhihong YangTing ZhangPraveen KusumanchiQing TangZhaoli SunSvetlana RadaevaBrandon PeifferVijay H ShahPatrick KamathGreg J GoresArun SanyalNaga P ChalasaniYanchao JiangNazmul HudaJing MaSuthat LiangpunsakulPublished in: Hepatology (Baltimore, Md.) (2021)
Patients with AH attempt to deal with hepatocyte injury by down-regulating specific miRNAs and up-regulating genes responsible for DNA synthesis and cell-cycle progression. Higher expression of these miRNAs, suggestive of a diminished capacity in liver regeneration, predicts short-term mortality in AH patients.
Keyphrases
- cell cycle
- stem cells
- end stage renal disease
- cell proliferation
- cardiovascular events
- ejection fraction
- newly diagnosed
- poor prognosis
- chronic kidney disease
- risk factors
- peritoneal dialysis
- cardiovascular disease
- type diabetes
- coronary artery disease
- gene expression
- single molecule
- binding protein
- patient reported outcomes
- patient reported
- nucleic acid