Immunohistochemical panel of degenerated articular discs from patients with temporomandibular joint osteoarthritis.
Bruno Viezzer FernandesJoão Armando BrancherArieli C MichelsSeigo NagashimaAline Cristina B R JohannMarianna Bóia FerreiraDelson J da CostaNelson Luis B RebellatoLeandro Eduardo KlüppelRafaela ScariotJoão C ZielakPublished in: Journal of oral rehabilitation (2020)
Angiogenesis and tissue fragmentation may result from aberrant physiologic responses mediated by VEGF and TNF-α, compromising TMJ discs during OA progression. The expression of TGF-β1, BMP-2 and IHH could be related to collagen degeneration in displaced discs and may participate in TMJOA pathogenesis.