Transgenic expression of human CD47 reduces phagocytosis of porcine endothelial cells and podocytes by baboon and human macrophages.

Shunichiro NomuraYuichi AriyoshiHironosuke WatanabeThomas PomposelliKazuhiro TakeuchiGabriela GarciaMasayuki TasakiDavid AyaresMegan SykesDavid H SachsRichard JohnsonKazuhiko Yamada

Published in: Xenotransplantation (2019)

The similar levels of phagocytosis of porcine cells by baboon and human macrophages suggest that the expression of hCD47Tg on glomerular cells in donor porcine kidneys may prove to be a key strategy for preventing proteinuria following kidney xenotransplantation in a pig-to-human as well as a pig-to-baboon model.

Keyphrases

endothelial cells
high glucose
induced pluripotent stem cells
induced apoptosis
poor prognosis
cell cycle arrest
oxidative stress
cell death
binding protein
endoplasmic reticulum stress