Cardiovascular effects of relaxin-2: therapeutic potential and future perspectives.
Nísia Almeida-PintoThomas Bernd DschietzigCarmen Brás-SilvaRui Miguel da Costa AdãoPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2023)
The hormone relaxin-2 has emerged as a promising player in regulating the physiology of the cardiovascular system. Through binding to the relaxin family peptide receptor 1 (RXFP1), this hormone elicits multiple physiological responses including vasodilation induction, reduction of inflammation and oxidative stress, and angiogenesis stimulation. The role of relaxin-2, or its recombinant human form known as serelaxin, has been investigated in preclinical and clinical studies as a potential therapy for cardiovascular diseases, especially heart failure, whose current therapy is still unoptimized. However, evidence from past clinical trials has been inconsistent and further research is needed to fully understand the potential applications of relaxin-2. This review provides an overview of serelaxin use in clinical trials and discusses future directions in the development of relaxin-2 mimetics, which may offer new therapeutic options for patients with heart failure.
Keyphrases
- clinical trial
- oxidative stress
- heart failure
- recombinant human
- cardiovascular disease
- randomized controlled trial
- dna damage
- left ventricular
- stem cells
- type diabetes
- human health
- cell therapy
- metabolic syndrome
- ischemia reperfusion injury
- signaling pathway
- coronary artery disease
- high resolution
- current status
- cardiovascular risk factors
- diabetic rats
- open label
- cardiac resynchronization therapy
- single molecule