Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1157-165 tumor-specific peptide.

Eugene ShenderovMatheswaran KandasamyUzi GileadiJili ChenDawn ShepherdJames GibbsGennaro ProtaJonathan D SilkJonathan W YewdellVincenzo Cerundolo

Published in: Journal for immunotherapy of cancer (2021)

The 1G4 TCR mouse model for the physiological human TCR against the clinically relevant antigen, NY-ESO-1, is a valuable tool with the potential to accelerate clinical development of NY-ESO-1-targeted T-cell and vaccine therapies.

Keyphrases

endothelial cells
regulatory t cells
mouse model
induced pluripotent stem cells
pluripotent stem cells
risk assessment
human health
climate change