Clinical trial design and analysis for comparing three treatments with intra-individual right- and left-hand data.
Ryunosuke MachidaKentaro SakamakiAya KuchibaPublished in: Clinical trials (London, England) (2023)
The proposed design can improve the power for comparing between two experimental treatments and the control treatment. Our design is useful in situations where it is undesirable for participants to receive different experimental treatments in both hands for practical reasons.