Diuretics decrease fluid balance in patients on invasive mechanical ventilation: the randomized-controlled single blind, IRIHS study.
Raphaël CinottiJean-Baptiste LascarrouMarie-Ange AzaisGwenhaël ColinJean-Pierre QuenotPierre-Joachim MahéAntoine RoquillyAurélie GaultierKarim AsehnouneJean ReignierPublished in: Critical care (London, England) (2021)
In this multicenter randomized-controlled study, protocolized diuretic therapy reduced fluid accumulation in patients receiving mechanical ventilation and was well tolerated with a favorable safety profile. Trial registration NCT02345681, Registered January 26 2015, Prospectively registered, https://clinicaltrials.gov/ct2/show/NCT02345681?term=02345681&draw=2&rank=1 .
Keyphrases
- mechanical ventilation
- acute respiratory distress syndrome
- phase iii
- double blind
- intensive care unit
- phase ii
- open label
- end stage renal disease
- respiratory failure
- placebo controlled
- clinical trial
- newly diagnosed
- ejection fraction
- chronic kidney disease
- computed tomography
- extracorporeal membrane oxygenation
- study protocol
- prognostic factors
- contrast enhanced
- heart failure
- stem cells
- patient reported outcomes
- randomized controlled trial
- mesenchymal stem cells
- bone marrow
- gestational age
- acute heart failure
- image quality