Lipid in microglial biology - from material to mediator.
Shota YamamotoTakahiro MasudaPublished in: Inflammation and regeneration (2023)
Microglia are resident macrophages in the central nervous system (CNS) that play various roles during brain development and in the pathogenesis of CNS diseases. Recently, reprogramming of cellular energetic metabolism in microglia has drawn attention as a crucial mechanism for diversification of microglial functionality. Lipids are highly diverse materials and crucial components of cell membranes in every cell. Accumulating evidence has shown that lipid and its metabolism are tightly involved in microglial biology. In this review, we summarize the current knowledge about microglial lipid metabolism in health and disease.
Keyphrases
- inflammatory response
- neuropathic pain
- lipopolysaccharide induced
- lps induced
- single cell
- healthcare
- fatty acid
- cell therapy
- spinal cord
- blood brain barrier
- public health
- mental health
- stem cells
- working memory
- quality improvement
- patient safety
- white matter
- multiple sclerosis
- bone marrow
- cerebral ischemia
- subarachnoid hemorrhage
- climate change
- health promotion
- emergency medicine