Evaluating the efficacy of endotracheal and intranasal epinephrine administration in severely asphyxic bradycardic newborn lambs: a randomised preclinical study.

Justine de JagerRomy PothofKelly J CrossleyGeorg Marcus SchmölzerArjan B Te PasRobert GalinskyNhi T TranNils Thomas SongstadClaus KlingenbergStuart B HooperGraeme R Polglase Calum Timothy Roberts

Published in: Archives of disease in childhood. Fetal and neonatal edition (2024)

Our study supports neonatal resuscitation guidelines, highlighting intravenous administration as the most effective route for epinephrine. ET and IN epinephrine should only be considered when intravenous access is delayed or not feasible.

Keyphrases

cardiac arrest
high dose
randomized controlled trial
stem cells
mesenchymal stem cells
low dose
bone marrow
cardiopulmonary resuscitation
septic shock
placebo controlled