AQP0 is a novel surface marker for deciphering abnormal erythropoiesis.

Tso-Fu WangGuan-Ling LinSung-Chao ChuChang-Chin ChenYu-Shan LiouHsin-Hou ChangDer-Shan Sun

Published in: Stem cell research & therapy (2021)

AQP0 was successfully demonstrated to be a marker of erythroid differentiation. The expression levels of AQP0 are downregulated in patients with dyserythropoiesis, indicating a critical role of AQP0 in erythropoiesis. Accordingly, the level of AQP0high in early erythroid precursor cells may serve as a reference parameter for diagnosing diseases associated with dyserythropoiesis.

Keyphrases

induced apoptosis
poor prognosis
signaling pathway
binding protein
cell proliferation
endoplasmic reticulum stress