Integrated Gut-Heart Axis and Network Pharmacology to Reveal the Mechanisms of the Huoxue Wentong Formula Against Myocardial Ischemia.

Jianguo LinQingqing WangXin HuaJinlong DuanKui-Wu Yao

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

This study demonstrates that HX treated MI rats in a multitarget and multipathway manner. Its mechanism is related to the change of gut microbiota and the regulation of valine, leucine and isoleucine biosynthesis, fatty acid biosynthesis, and arachidonic acid metabolism.

Keyphrases

fatty acid
heart failure
cell wall
left ventricular
single cell
genome wide
human milk
gene expression
dna methylation
preterm infants
newly diagnosed