Induced Mitochondrial Alteration and DNA Damage via IFNGR-JAK2-STAT1-PARP1 Pathway Facilitates Viral Hepatitis Associated Hepatocellular Carcinoma Aggressiveness and Stemness.
Yih-Giun CherngYi Cheng ChuVijesh Kumar YadavTing-Yi HuangMing-Shou HsiehKwai-Fong LeeWei-Hwa LeeChi-Tai YehJiann Ruey OngPublished in: Cancers (2021)
Our results showed that momelotinib effectively suppressed the expression of the IFNGR-JAK-STAT-PARP1 pathway, which results in the downregulation of cancer stem cell genes and enhances the antitumor efficacy of sorafenib by initiating the expression of apoptosis-related genes and inhibiting the DNA repair gene in vHCC cells, thus maximizing its therapeutic potential for patients with HCC.
Keyphrases
- dna repair
- dna damage
- oxidative stress
- cancer stem cells
- cell cycle arrest
- poor prognosis
- induced apoptosis
- diabetic rats
- dna damage response
- signaling pathway
- genome wide
- cell death
- stem cells
- endoplasmic reticulum stress
- sars cov
- epithelial mesenchymal transition
- pi k akt
- binding protein
- copy number
- dna methylation
- genome wide analysis
- long non coding rna
- gene expression
- endothelial cells