Diverse Profiles of Toll-Like Receptors 2, 4, 7, and 9 mRNA in Peripheral Blood and Biopsy Specimens of Patients with Celiac Disease.
Haniye GhasiyariMohammad Rostami-NejadDavar AmaniKamran RostamiMohamad Amin PourhoseingholiHamid Asadzadeh-AghdaeiMohammad Reza ZaliPublished in: Journal of immunology research (2018)
The alteration of TLR4 and TLR9 expression in the blood and biopsy samples of patients with CD supports the critical role of the innate immune system in the pathogenesis of this disease. Upregulation of TLR4 and TLR9 suggests the contribution of gut microbiota or dysregulation of the immune response to commensal flora in small bowel mucosa in celiac patients.
Keyphrases
- immune response
- toll like receptor
- celiac disease
- inflammatory response
- peripheral blood
- small bowel
- end stage renal disease
- poor prognosis
- fine needle aspiration
- nuclear factor
- chronic kidney disease
- newly diagnosed
- ejection fraction
- ultrasound guided
- peritoneal dialysis
- prognostic factors
- signaling pathway
- long non coding rna