Randomized controlled trial on the effect of 1-hour infusion of vincristine versus push injection on neuropathy in children with cancer (final analysis).
Aniek UittenboogaardMarleen H van den BergFloor C H AbbinkJos W R TwiskInge M van der SluisCor van den BosMarry M van den Heuvel-EibrinkHeidi SegersChristophe ChantrainJutte van der Werff Ten BoschLeen WillemsGertjan J L KaspersMirjam Esther van de VeldePublished in: Cancer medicine (2023)
1-hour infusion of vincristine is not protective against VIPN. However, in patients receiving concurrent azoles, 1-hour infusion may be less toxic. The difference in treatment outcome is most likely the result of differences in risk profile.