PD-L1 Expression in Neoplastic and Immune Cells of Thymic Epithelial Tumors: Correlations with Disease Characteristics and HDAC Expression.

Ioanna E Stergiou Kostantinos Palamaris Georgia LevidouMaria TzimouStavros P Papadakos Georgios MandrakisChristos MasaoutisDimitra RontogianniStamatios Theocharis

Published in: Biomedicines (2024)

Higher PD-L1 expression in neoplastic cells and lower PD-L1 expression in immune cells of TETs characterizes more aggressive and advanced neoplasms. Correlations between PD-L1 and HDAC expression unravel the impact of epigenetic regulation on the expression of immune checkpoint molecules in TETs, with possible future applications in combined therapeutic targeting.

Keyphrases

poor prognosis
binding protein
induced apoptosis
long non coding rna
histone deacetylase
oxidative stress