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PD-L1 Expression in Neoplastic and Immune Cells of Thymic Epithelial Tumors: Correlations with Disease Characteristics and HDAC Expression.

Ioanna E StergiouKostantinos PalamarisGeorgia LevidouMaria TzimouStavros P PapadakosGeorgios MandrakisChristos MasaoutisDimitra RontogianniStamatios Theocharis
Published in: Biomedicines (2024)
Higher PD-L1 expression in neoplastic cells and lower PD-L1 expression in immune cells of TETs characterizes more aggressive and advanced neoplasms. Correlations between PD-L1 and HDAC expression unravel the impact of epigenetic regulation on the expression of immune checkpoint molecules in TETs, with possible future applications in combined therapeutic targeting.
Keyphrases
  • poor prognosis
  • binding protein
  • induced apoptosis
  • long non coding rna
  • histone deacetylase
  • oxidative stress