Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease.
Nelly Joseph-MathurinGuoqiao WangKejal KantarciClifford R JackEric McDadeJason HassenstabTyler M BlazeyBrian A GordonYi SuGengsheng ChenParinaz MassoumzadehRuss C HornbeckRicardo F AllegriBeau M AncesSarah B BermanAdam M BrickmanWilliam S BrooksDavid M CashJasmeer P ChhatwalHelena C ChuiStephen CorreiaCruchaga CarlosMartin R FarlowNick C FoxMichael J FulhamBernardino GhettiNeill R Graff-RadfordKeith A JohnsonCeleste M KarchChristoph LaskeAthene K W LeeJohannes LevinColin L MastersJames M NobleAntoinette O'ConnorRichard J PerrinGregory M PreboskeJohn M RingmanChristopher C RoweStephen SallowayAndrew J SaykinPeter R SchofieldHiroyuki ShimadaMikio ShojiKazushi SuzukiVictor L VillemagneChengjie XiongIgor YakushevJohn C MorrisRandell J BatemanTammie L S Benzingernull nullPublished in: Neurology (2021)
Our study highlights factors associated with the development of CMHs in individuals with DIAD. CMHs are a part of the underlying disease process in DIAD and are significantly associated with dementia. This highlights that in participants in treatment trials exposed to drugs, which carry the risk of ARIA-H as a complication, it may be challenging to separate natural incidence of CMHs from drug-related CMHs.