Proof-of-concept randomized controlled trial of single-session nitrous oxide treatment for refractory bipolar depression: Focus on cerebrovascular target engagement.
William S H KimMikaela K DimickDanielle OmrinRachel H B MitchellDaniel RiegertAnthony LevittAyal SchafferSusan BeloJohn IazzettaGarfield DetzlerMabel ChoiStephen ChoiNathan HerrmannRoger S McIntyreBradley J MacIntoshBeverley A OrserBenjamin I GoldsteinPublished in: Bipolar disorders (2022)
Present findings, while tentative and based on secondary endpoints, suggest differential associations of nitrous oxide versus midazolam with bipolar depression severity and cerebral hemodynamics. Larger studies integrating neuroimaging targets and repeated nitrous oxide treatment sessions are warranted.