Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts.

Albert Gris-OliverMarta PalafoxLaia MonserratFara Brasó-MaristanyAndreu ÒdenaMònica Sánchez-GuixéYasir H IbrahimGuillermo VillacampaJudit GruesoMireia ParésMarta GuzmánOlga RodríguezAlejandra BrunaCaroline S HirstAlan BarnicleElza C de BruinAvinash ReddyGaia SchiavonJoaquín Arribas Gordon B MillsCarlos CaldasRodrigo DienstmannAleix PratPaolo G NuciforoPedram RazaviMaurizio ScaltritiNicholas C TurnerCristina SauraBarry R DaviesMafalda Oliveira Violeta Serra

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

This study provides insight into putative predictive biomarkers of response and acquired resistance to AZD5363 in HER2-negative metastatic breast cancer.

Keyphrases

metastatic breast cancer
signaling pathway
cell proliferation
genome wide
copy number
gene expression
dna methylation