Maurizio Scaltriti

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 34

Top Topics

Metastatic Breast Cancer

Genetic Diversity

Tyrosine Kinase

Gene Expression

Top Venues

Clinical cancer research : an official journal of the American Association for Cancer Research

Nature communications

Cancer research

Cancer discovery

This page only lists publications with an associated author ORCID identifier.

Publications

Smruthy S Sivakumar, Dexter X Jin, Ruchita Rathod, Jeffery S Ross, Lewis C Cantley, Maurizio Scaltriti, Jessica W Chen, Katherine E Hutchinson, Timothy R Wilson, Ethan S Sokol, Neil Vasan
Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Smruthy S Sivakumar, Dexter X Jin, Ruchita Rathod, Jeffery S Ross, Lewis C Cantley, Maurizio Scaltriti, Jessica W Chen, Katherine E Hutchinson, Timothy R Wilson, Ethan S Sokol, Neil Vasan
Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Smruthy S Sivakumar, Dexter X Jin, Ruchita Rathod, Jeffery S Ross, Lewis C Cantley, Maurizio Scaltriti, Jessica W Chen, Katherine E Hutchinson, Timothy R Wilson, Ethan S Sokol, Neil Vasan
Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Smruthy S Sivakumar, Dexter X Jin, Ruchita Rathod, Jeffery S Ross, Lewis C Cantley, Maurizio Scaltriti, Jessica W Chen, Katherine E Hutchinson, Timothy R Wilson, Ethan S Sokol, Neil Vasan
Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Smruthy S Sivakumar, Dexter X Jin, Ruchita Rathod, Jeffery S Ross, Lewis C Cantley, Maurizio Scaltriti, Jessica W Chen, Katherine E Hutchinson, Timothy R Wilson, Ethan S Sokol, Neil Vasan
Genetic heterogeneity and tissue-specific patterns of tumors with multiple PIK3CA mutations. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Erik Ladewig, Flavia Michelini, Komal Jhaveri, Hatice Ulku Osmanbeyoglu, Javier Carmona, Lauren Fairchild, Adler G Zuniga, Amaia Arruabarrena-Aristorena, Emiliano Cocco, Ryan Blawski, Srushti Kittane, Yuhan Zhang, Mirna Sallaku, Laura Baldino, Vasilis Hristidis, Sarat Chandarlapaty, Omar Abdel-Wahab, Christina S Leslie, Maurizio Scaltriti, Eneda Toska
The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation. Cancer research 82 (12) (2022)
Marta Palafox, Laia Monserrat, Meritxell Bellet, Guillermo Villacampa, Nuria Lopez-Bigas, Mafalda Oliveira, Fara Brasó-Maristany, Nusaibah Ibrahimi, Srinivasaraghavan Kannan, Leonardo Mina, Maria Teresa Herrera-Abreu, Andreu Òdena, Mònica Sánchez-Guixé, Marta Capelán, Analía Azaro, Alejandra Bruna, Olga Rodríguez, Marta Guzmán, Judit Grueso, Cristina Viaplana, Javier Hernández-Losa, Faye Su, Kui Lin, Robert B Clarke, Carlos Caldas, Joaquín Arribas, Stefan Michiels, Alicia García-Sanz, Nicholas C Turner, Aleix Prat, Paolo G Nuciforo, Rodrigo Dienstmann, Chandra S Verma, Núria López-Bigas, Maurizio Scaltriti, Monica Arnedos, Cristina Saura, Violeta Serra
Author Correction: High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER + breast cancer. Nature communications 13 (1) (2022)
Marta Palafox, Laia Monserrat, Meritxell Bellet, Guillermo Villacampa, Nuria Lopez-Bigas, Mafalda Oliveira, Fara Brasó-Maristany, Nusaibah Ibrahimi, Srinivasaraghavan Kannan, Leonardo Mina, Maria Teresa Herrera-Abreu, Andreu Òdena, Mònica Sánchez-Guixé, Marta Capelán, Analía Azaro, Alejandra Bruna, Olga Rodríguez, Marta Guzmán, Judit Grueso, Cristina Viaplana, Javier Hernández-Losa, Faye Su, Kui Lin, Robert B Clarke, Carlos Caldas, Joaquín Arribas, Stefan Michiels, Alicia García-Sanz, Nicholas C Turner, Aleix Prat, Paolo G Nuciforo, Rodrigo Dienstmann, Chandra S Verma, Núria López-Bigas, Maurizio Scaltriti, Monica Arnedos, Cristina Saura, Violeta Serra
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER + breast cancer. Nature communications 13 (1) (2022)
Konstantinos V Floros, Sheeba Jacob, Richard Kurupi, Carter K Fairchild, Bin Hu, Madhavi Puchalapalli, Jennifer E Koblinski, Mikhail G Dozmorov, Sosipatros A Boikos, Maurizio Scaltriti, Anthony C Faber
Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors. Cell death & disease 12 (2) (2021)
Nina Radosevic-Robin, Pier Selenica, Yingjie Zhu, Helen H Won, Michael F Berger, Lorenzo Ferrando, Emiliano Cocco, Maud Privat, Flora Ponelle-Chachuat, Catherine Abrial, Jean-Marc Nabholtz, Frederique Penault-Llorca, Jorge Sergio Reis-Filho, Maurizio Scaltriti
Recurrence biomarkers of triple negative breast cancer treated with neoadjuvant chemotherapy and anti-EGFR antibodies. NPJ breast cancer 7 (1) (2021)
Jorge Gomez Tejeda Zanudo, Pingping Mao, Clara Alcon, Kailey Kowalski, Gabriela N Johnson, Guotai Xu, Jose Baselga, Maurizio Scaltriti, Anthony G Letai, Joan Montero, Reka Albert, Nikhil Wagle
Cell Line-Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations. Cancer research 81 (17) (2021)
Wei Xie, Shengliu Wang, Juncheng Wang, M Jason de la Cruz, Guotai Xu, Maurizio Scaltriti, Dinshaw J Patel
Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex. Proceedings of the National Academy of Sciences of the United States of America 118 (8) (2021)
Hatice Ulku Osmanbeyoglu, Eneda Toska, Jeffrey A Engelman, Maurizio Scaltriti
The present and future of PI3K inhibitors for cancer therapy. Nature cancer 2 (6) (2021)
Andrew L Wolfe, Qingwen Zhou, Eneda Toska, Jacqueline Galeas, Angel A Ku, Richard P Koche, Sourav Bandyopadhyay, Maurizio Scaltriti, Carlito B Lebrilla, Frank McCormick, Sung Eun Kim
UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth. Proceedings of the National Academy of Sciences of the United States of America 118 (31) (2021)
Mònica Sánchez-Guixé, Cinta Hierro, José Jiménez, Cristina Viaplana, Guillermo Villacampa, Erika Monelli, Fara Brasó-Maristany, Zighereda Ogbah, Mireia Parés, Marta Guzmán, Judit Grueso, Olga Rodríguez, Mafalda Oliveira, Analía Azaro, Elena Garralda, Josep Tabernero, Oriol Casanovas, Maurizio Scaltriti, Aleix Prat, Rodrigo Dienstmann, Paolo G Nuciforo, Cristina Saura, Mariona Graupera, Ana Vivancos, Jordi Rodon, Violeta Serra
High FGFR1-4 mRNA Expression Levels Correlate with Response to Selective FGFR Inhibitors in Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Andrea Caporali, Steven Fawell, Maurizio Scaltriti
How a new drug is born. European heart journal 42 (32) (2021)
Yanyan Cai, Guotai Xu, Fan Wu, Flavia Michelini, Carmen Chan, Xuan Qu, Pier Selenica, Erik Ladewig, Hatice Ulku Osmanbeyoglu, Yuanming Cheng, Alison Zhao, Komal Jhaveri, Eneda Toska, Marta Jimenez, Alexandra Jacquet, Alicia Tran-Dien, Fabrice Andre, Sarat Chandarlapaty, Jorge S Reis-Filho, Pedram Razavi, Maurizio Scaltriti
Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors. Cancer research 81 (9) (2021)
Lillian M Smyth, Kenji Tamura, Mafalda Oliveira, Eva Ciruelos Gil, Ingrid A Mayer, Marie-Paule Sablin, Laura Biganzoli, Helen J Ambrose, Jack Ashton, Alan Barnicle, Des D Cashell, Claire Corcoran, Elza C de Bruin, Andrew Foxley, Joana Hauser, Justin P O Lindemann, Rhiannon Maudsley, Robert McEwen, Michele Moschetta, Martin Pass, Vicky Rowlands, Gaia Schiavon, Udai Banerji, Maurizio Scaltriti, Barry S Taylor, Sarat Chandarlapaty, José Baselga, David M Hyman
Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with AKT1 E17K-Mutant, ER-Positive Metastatic Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (15) (2020)
Guotai Xu, Sagar Chhangawala, Emiliano Cocco, Pedram Razavi, Yanyan Cai, Jordan E Otto, Lorenzo Ferrando, Pier Selenica, Erik Ladewig, Carmen Chan, Arnaud Da Cruz Paula, Matthew Witkin, Yuanming Cheng, Jane Park, Cristian Serna-Tamayo, HuiYong Zhao, Fan Wu, Mirna Sallaku, Xuan Qu, Alison Zhao, Clayton K Collings, Andrew R D'Avino, Komal Jhaveri, Richard P Koche, Ross L Levine, Jorge Sergio Reis-Filho, Cigall Kadoch, Maurizio Scaltriti, Christina S Leslie, Jose Baselga, Eneda Toska
ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer. Nature genetics 52 (2) (2020)
Kwanghee Kim, Wenhuo Hu, Francois Audenet, Nima Almassi, Aphrothiti J Hanrahan, Katie S Murray, Aditya Bagrodia, Nathan Wong, Timothy N Clinton, Shawn Dason, Vishnu Mohan, Sylvia Jebiwott, Karan Nagar, Jianjiong Gao, Alexander V Penson, Chris Hughes, Benjamin Gordon, Ziyu Chen, Yiyu Dong, Philip A Watson, Ricardo Alvim, Arijh Elzein, Sizhi P Gao, Emiliano Cocco, Alessandro D Santin, Irina Ostrovnaya, James J Hsieh, Irit Sagi, Eugene J Pietzak, Abraham Ari Hakimi, Jonathan E Rosenberg, Gopakumar V Iyer, Herbert A Vargas, Maurizio Scaltriti, Hikmat A Al-Ahmadie, David B Solit, Jonathan A Coleman
Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts. Nature communications 11 (1) (2020)
Bob T Li, Flavia Michelini, Sandra Misale, Emiliano Cocco, Laura Baldino, Yanyan Cai, Sophie Shifman, Hai-Yan Tu, Mackenzie L Myers, Chong-Rui Xu, Marissa Mattar, Inna Khodos, Megan Little, Besnik Qeriqi, Gregory Weitsman, Clare J Wilhem, Alshad S Lalani, Irmina Diala, Rachel A Freedman, Nancy U Lin, David B Solit, Michael F Berger, Paul R Barber, Tony Ng, Michael D Offin, James M Isbell, David R Jones, Helena A Yu, Sheeno Thyparambil, Wei-Li Liao, Anuja Bhalkikar, Fabiola Cecchi, David M Hyman, Jason S Lewis, Darren J Buonocore, Alan L Ho, Vicky Makker, Jorge S Reis-Filho, Pedram Razavi, Maria E Arcila, Mark G Kris, John T Poirier, Ronglai Shen, Junji Tsurutani, Gary A Ulaner, Elisa de Stanchina, Neal X Rosen, Charles M Rudin, Maurizio Scaltriti
HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers. Cancer discovery 10 (5) (2020)
Alexander N Gorelick, Francisco J Sánchez Rivera, Yanyan Cai, Craig M Bielski, Evan Biederstedt, Philip Jonsson, Allison L Richards, Neil Vasan, Alexander V Penson, Noah D Friedman, Yu-Jui Ho, Timour Baslan, Chaitanya Bandlamudi, Maurizio Scaltriti, Nikolaus Schultz, Scott W Lowe, Ed Reznik, Barry S Taylor
Phase and context shape the function of composite oncogenic mutations. Nature 582 (7810) (2020)
Albert Gris-Oliver, Marta Palafox, Laia Monserrat, Fara Brasó-Maristany, Andreu Òdena, Mònica Sánchez-Guixé, Yasir H Ibrahim, Guillermo Villacampa, Judit Grueso, Mireia Parés, Marta Guzmán, Olga Rodríguez, Alejandra Bruna, Caroline S Hirst, Alan Barnicle, Elza C de Bruin, Avinash Reddy, Gaia Schiavon, Joaquín Arribas, Gordon B Mills, Carlos Caldas, Rodrigo Dienstmann, Aleix Prat, Paolo G Nuciforo, Pedram Razavi, Maurizio Scaltriti, Nicholas C Turner, Cristina Saura, Barry R Davies, Mafalda Oliveira, Violeta Serra
Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (14) (2020)
Neil Vasan, Pedram Razavi, Jared L Johnson, Hong Shao, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander N Gorelick, Ting-Yu Lin, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T Chang, Barry S Taylor, Maura N Dickler, Komal Jhaveri, Sarat Chandarlapaty, Raúl Rabadán, Ed Reznik, Melissa Laird Smith, Robert Sebra, Frauke Schimmoller, Timothy R Wilson, Lori S Friedman, Lewis C Cantley, Maurizio Scaltriti, Jose Baselga
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. Science (New York, N.Y.) 366 (6466) (2020)
Komal Jhaveri, Matthew T Chang, Dejan Juric, Cristina Saura, Valentina Gambardella, Anton Melnyk, Manish R Patel, Vincent Ribrag, Cynthia X Ma, Raid Aljumaily, Philippe L Bedard, Jasgit C Sachdev, Lara Dunn, Helen H Won, John Bond, Surai Jones, Heidi M Savage, Maurizio Scaltriti, Timothy R Wilson, Michael C Wei, David M Hyman
Phase I Basket Study of Taselisib, an Isoform-Selective PI3K Inhibitor, in Patients with PIK3CA-Mutant Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (2) (2020)
Emiliano Cocco, Ji Eun Lee, Srinivasaraghavan Kannan, Alison M Schram, Helen H Won, Sophie Shifman, Amanda Kulick, Laura Baldino, Eneda Toska, Amaia Arruabarrena-Aristorena, Srushti Kittane, Fan Wu, Yanyan Cai, Sabrina Arena, Benedetta Mussolin, Neil Vasan, Alexander N Gorelick, Michael F Berger, Ofra Novoplansky, Sankar Jagadeeshan, Yi Liao, Uwe Rix, Sandra Misale, Barry S Taylor, Alberto Bardelli, Jaclyn F Hechtman, David M Hyman, Moshe Elkabets, Elisa de Stanchina, Chandra S Verma, Andrea Ventura, Alexander E Drilon, Maurizio Scaltriti
TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors. Cancer discovery 11 (1) (2020)
Lillian M Smyth, Sarina A Piha-Paul, Helen H Won, Alison M Schram, Cristina Saura, Sherene Loi, Janice Lu, Geoffrey I Shapiro, Dejan Juric, Ingrid A Mayer, Carlos L Arteaga, Macarena I de la Fuente, Adam M Brufksy, Iben Spanggaard, Morten Mau Sorensen, Monica Arnedos, Victor Moreno, Valentina Boni, Joohyuk Sohn, Lee S Schwartzberg, Xavier Gonzalez, Andres Cervantes, François-Clement Bidard, Alexander N Gorelick, Richard B Lanman, Rebecca J Nagy, Gary A Ulaner, Sarat Chandarlapaty, Komal Jhaveri, Elena I Gavrila, Catherine Zimel, S Duygu Selcuklu, Myra Melcer, Aliaksandra Samoila, Yanyan Cai, Maurizio Scaltriti, Grace Mann, Feng Xu, Lisa D Eli, Melanie Dujka, Alshad S Lalani, Richard Bryce, José Baselga, Barry S Taylor, David B Solit, Funda Meric-Bernstam, David M Hyman
Efficacy and Determinants of Response to HER Kinase Inhibition in HER2-Mutant Metastatic Breast Cancer. Cancer discovery 10 (2) (2019)
Ofra Novoplansky, Matthew Fury, Manu Prasad, Ksenia Yegodayev, Jonathan Zorea, Limor Cohen, Raphael Pelossof, Liz Cohen, Nora Katabi, Fabiola Cecchi, Ben-Zion Joshua, Aron Popovtzer, Jose Baselga, Maurizio Scaltriti, Moshe Elkabets
MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer. International journal of cancer 145 (3) (2019)
Irene Rius Ruiz, Rocio Vicario, Beatriz Morancho, Cristina Bernadó Morales, Enrique J Arenas Lahuerta, Sylvia Herter, Anne Freimoser-Grundschober, Jitka Somandin, Johannes Sam, Oliver Ast, Águeda Martinez Barriocanal, Antonio Luque, Marta Escorihuela, Ismael Varela, Isabel Cuartas, Paolo G Nuciforo, Roberta Fasani, Vicente Peg, Isabel Rubio, Javier Cortes, Violeta Serra, Santiago Escriva-de-Romani, Jeff Sperinde, Ahmed Chenna, Weidong Huang, John Winslow, Joan Albanell, Joan Seoane, Maurizio Scaltriti, Jose Baselga, Josep Tabernero, Pablo Umana, Marina Bacac, Cristina Saura, Christiane Neumann, Joaquín Arribas
p95HER2-T cell bispecific antibody for breast cancer treatment. Science translational medicine 10 (461) (2019)
Ezra Y Rosen, Debra A Goldman, Jaclyn F Hechtman, Ryma Benayed, Alison M Schram, Emiliano Cocco, Sophie Shifman, Yixiao Gong, Ritika Kundra, James P Solomon, Alberto Bardelli, Maurizio Scaltriti, Alexander E Drilon, Alexia Iasonos, Barry S Taylor, David M Hyman
TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (7) (2019)
Ilaria Alborelli, Daniele Generali, Philip Jermann, Maria Rosa Cappelletti, Giuseppina Ferrero, Bruna Scaggiante, Marina Bortul, Fabrizio Zanconati, Stefan Nicolet, Jasmin Haegele, Lukas Bubendorf, Nicola Aceto, Maurizio Scaltriti, Giuseppe Mucci, Luca Quagliata, Giuseppe Novelli
Cell-free DNA analysis in healthy individuals by next-generation sequencing: a proof of concept and technical validation study. Cell death & disease 10 (7) (2019)
Emiliano Cocco, Alison M Schram, Amanda Kulick, Sandra Misale, Helen H Won, Rona Yaeger, Pedram Razavi, Ryan Ptashkin, Jaclyn F Hechtman, Eneda Toska, James Cownie, Romel Somwar, Sophie Shifman, Marissa Mattar, S Duygu Selçuklu, Aliaksandra Samoila, Sean Guzman, Brian B Tuch, Kevin Ebata, Elisa de Stanchina, Rebecca J Nagy, Richard B Lanman, Brian Houck-Loomis, Juber A Patel, Michael F Berger, Marc Ladanyi, David M Hyman, Alexander E Drilon, Maurizio Scaltriti
Resistance to TRK inhibition mediated by convergent MAPK pathway activation. Nature medicine 25 (9) (2019)
Emiliano Cocco, F Javier Carmona, Pedram Razavi, Helen H Won, Yanyan Cai, Valentina Rossi, Carmen Chan, James Cownie, Joanne Soong, Eneda Toska, Sophie G Shifman, Ivana Sarotto, Peter Savas, Michael J Wick, Kyriakos P Papadopoulos, Alyssa Moriarty, Richard E Cutler, Francesca Avogadri-Connors, Alshad S Lalani, Richard P Bryce, Sarat Chandarlapaty, David M Hyman, David B Solit, Valentina Boni, Sherene Loi, Jose Baselga, Michael F Berger, Filippo Montemurro, Maurizio Scaltriti
Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2). Science signaling 11 (551) (2018)
Eneda Toska, Hatice U Osmanbeyoglu, Hatice Ulku Osmanbeyoglu, Carmen Chan, Ronald C Hendrickson, Moshe Elkabets, Maura N Dickler, Maurizio Scaltriti, Christina S Leslie, Scott A Armstrong, Jose Baselga
PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D. Science (New York, N.Y.) 355 (6331) (2017)