Protocol for Obtaining Platelet-Rich Plasma (PRP), Platelet-Poor Plasma (PPP), and Thrombin for Autologous use.

The reviewed article titled "Protocol for obtaining platelet-rich plasma (PRP), plateletpoor plasma (PPP), and thrombin for autologous use" by Franco et al. presents the authors' protocol for obtaining these substances. While acknowledging the potential of PRP in tissue healing and regeneration, concerns are raised regarding the lack of specific methodologies in PRP preparation and characterization, including platelet counts and leukocyte concentration. The use of non-activated platelets is suggested to yield better outcomes compared to activated platelets. Further analysis is needed to draw valid conclusions on PRP applications in aesthetic and regenerative medicine. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .