Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities.
Shamaine Wei Ting HoTaotao ShengManjie XingWen Fong OoiChang XuRaghav SundarKie Kyon HuangZhimei LiVikrant KumarKalpana RamnarayananFeng ZhuSupriya SrivastavaZul Fazreen Bin Adam IsaChukwuemeka George Anene-NzeluMilad Razavi-MohseniDustin ShigakiHaoran MaAngie Lay Keng TanXuewen OngMing Hui LeeSu Ting TayYu Amanda GuoWeitai HuangShang LiMichael A BeerRoger Sik Yin FooMing TehAnders Jacobsen SkanderupBin Tean TehPatrick Boon-Ooi TanPublished in: Gut (2022)
Our results establish a consensus Mes-GC classifier applicable to multiple transcriptomic scenarios. Mes-GCs exhibit a distinct epigenomic landscape, and TEAD1 inhibition and combinatorial NUAK1 inhibition/cisplatin may represent potential targetable options.