Decreased Annexin A1 expression enhances sensitivity to docetaxel, cisplatin and 5-fluorouracil combination induction chemotherapy in oral squamous cell carcinoma.

Wenwen SunTongchao ZhaoTimothy O AladelusiWutong JuZhiyuan ZhangLaiping ZhongDongwang Zhu

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2021)

Annexin A1 may be of prognostic value in patients with locally advanced OSCC who are managed with TPF chemotherapy, as low Annexin A1 promotes chemosensitivity to TPF chemotherapy in oral cancer cells via enhanced caspase-dependent apoptosis.

Keyphrases

locally advanced
rectal cancer
neoadjuvant chemotherapy
squamous cell carcinoma
radiation therapy
phase ii study
cell death
poor prognosis
oxidative stress
clinical trial
cell cycle arrest
cell proliferation
signaling pathway
binding protein