Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice.

Rong ChenThorsten Hornemann Sasa Stefanic Elisabeth M SchranerRichard ZuelligTheresia Reding Ermanno Malagola Darren C Henstridge Andrew P Hills Rolf Graf Sabrina Sonda

Published in: Diabetologia (2020)

Our results suggest that 1-deoxysphingolipids directly damage the functionality of pancreatic acinar cells and highlight that an L-serine-enriched diet may be used as a promising prophylactic intervention to reduce the severity of pancreatitis in the context of diabetes.

Keyphrases

type diabetes
cardiovascular disease
induced apoptosis
glycemic control
randomized controlled trial
cell cycle arrest
oxidative stress
protein kinase
physical activity
high fat diet induced
endoplasmic reticulum stress
adipose tissue
cell proliferation