Palmitate-induced Slc2a4/GLUT4 downregulation in L6 muscle cells: evidence of inflammatory and endoplasmic reticulum stress involvement.

Patrícia Ebersbach-SilvaAna Cláudia PolettoAline David-SilvaPatrícia Monteiro SeraphimGabriel Forato AnhêMarisa PassarelliDaniela Tomie FuruyaUbiratan Fabres Fabres Machado

Published in: Lipids in health and disease (2018)

Different pathways are activated in acute and chronic palmitate induced-repression of Slc2a4/GLUT4 expression. This regulation involves activation of initial component of ER stress, such as the formation of a IRE1a-TRAF2-IKK complex, and converges to NFKB-induced repression of Slc2a4/GLUT4. These results link ER stress, inflammation and insulin resistance in L6 cells.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
oxidative stress
diabetic rats
drug induced
high glucose
signaling pathway
poor prognosis
hepatitis b virus
extracorporeal membrane oxygenation
binding protein
mechanical ventilation