Partial endothelial-to-mesenchymal transition mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation.
Yoshito YamashiroKarina RamirezKazuaki NagayamaNaoko HattoriYu-Yu LiuShinji MatsunagaShuhei TomitaYoshiaki KubotaHiromi YanagisawaPublished in: Cardiovascular research (2022)
Our study identifies ECs as an origin of neointima, which is generated through partial EndMT and provides new evidence to the long-debated origin of neointimal cells after vascular injury. The ectopic CD45 expression in ECs is involved in the maintenance of endothelial cell-cell junction during EndMT process. Our data suggests a potential therapeutic strategy targeting the EndMT process to control neointima formation.
Keyphrases
- smooth muscle
- endothelial cells
- high glucose
- induced apoptosis
- poor prognosis
- stem cells
- cell cycle arrest
- bone marrow
- single cell
- cell therapy
- genome wide
- electronic health record
- nk cells
- diabetic rats
- vascular smooth muscle cells
- big data
- binding protein
- long non coding rna
- dna methylation
- gene expression
- data analysis
- deep learning
- pi k akt