Erythema multiforme associated with anti-plakin antibodies: a multicentric retrospective case series.
Amandine WeillVincent DescampsFrançois ChassetThibault MahevasI Bourgault-VilladaPierre WolkensteinS Chollet-MartinSaskia Ingen Housz OroS Grootenboer-MignotPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)
The rationale for anti-PLK-Ab detection in EM is not elucidated. More systematic research of anti-PLK-Abs is warranted to better understand whether this association reflects humoral immune activity in a subset of EM or is fortuitous, related to an epitope spreading process. However, EM-PLK+ seems to be associated with major and relapsing subtypes, and difficult-to-treat cases.