Fenofibrate up-regulated PPARα/PGC-1α signaling pathway, promoted mitochondrial β-oxidation, reduced oxidative stress damage and lipid accumulation of liver. PGC-1α overexpression enhanced mitochondrial biosynthesis and ATP production, and reduced HepG2 intracellular accumulation of lipids and oxidative stress.
Keyphrases
- oxidative stress
- signaling pathway
- skeletal muscle
- induced apoptosis
- insulin resistance
- pi k akt
- diabetic rats
- dna damage
- ischemia reperfusion injury
- epithelial mesenchymal transition
- fatty acid
- transcription factor
- cell proliferation
- room temperature
- reactive oxygen species
- metabolic syndrome
- endoplasmic reticulum stress
- electron transfer
- heat shock protein