LGR6 marks nephron progenitor cells.
Ravian L van IneveldThanasis MargaritisBerend A P KooimanFemke GroenveldHendrikus C R AriesePhilip LijnzaadHannah R JohnsonJeroen KorvingEllen J WehrensFrank HolstegeJacco van RheenenJarno DrostAnne C RiosFrank L BosPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)
Given the profound early mesenchymal expression and MET signature of LGR6+ cells, together with the lineage tracing of mesenchymal LGR6+ cells, we conclude that LGR6+ cells contribute to all nephrogenic segments by undergoing MET. LGR6+ cells can therefore be considered an early committed NPC population during embryonic and postnatal nephrogenesis with potential regenerative capability.