Safety of intra-arterial chemotherapy with or without osmotic blood-brain barrier disruption for the treatment of patients with brain tumors.

Kutluay Uluc Prakash Ambady Matthew K McIntyre John Philip Tabb Cymon N Kersch Caleb S NerisonAmy HuddlestonJesse J Liu Aclan Dogan Ryan A Priest Rongwei Fu Joao Prola Netto Dominic A Siler Leslie L Muldoon Seymur Gahramanov Edward A Neuwelt

Published in: Neuro-oncology advances (2022)

We provide safety and tolerability data from the largest cohort of consecutive patients who received IA or IA/OBBBD. Our data demonstrate that IA or IA/OBBBD safely enhance drug delivery to brain tumors and brain around the tumor.

Keyphrases

blood brain barrier
drug delivery
cerebral ischemia
electronic health record
big data
white matter
locally advanced
open label
clinical trial
cancer therapy
squamous cell carcinoma
randomized controlled trial
machine learning
radiation therapy
combination therapy
brain injury
chemotherapy induced