ACSL4-Mediated Membrane Phospholipid Remodeling Induces Integrin β1 Activation to Facilitate Triple-Negative Breast Cancer Metastasis.

Yuxiang Qiu Xing Wang Yan Sun Ting Jin Rui Tang Xinyue Zhou Ming Xu Yubi Gan Rui Wang Haojun Luo Manran Liu Xi Tang

Published in: Cancer research (2024)

ACSL4 upregulation in triple-negative breast cancer alters cell membrane phospholipid composition to increase integrin β1 activation and drive metastasis, indicating that targeting ACSL4 could potentially block metastasis and improve patient outcomes.

Keyphrases

cell proliferation
signaling pathway
poor prognosis
cell migration