Genetics of human startle reactivity: A systematic review to acquire targets for an anxiety endophenotype.

Julia TomasiClement C ZaiGwyneth ZaiAyeshah G MohiuddinArun K Tiwari

Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2020)

Similar to psychiatric genetic studies, the studies on startle reactivity primarily focus on candidate genes and are plagued by non-replication. Startle reactivity is a promising endophenotype that requires concerted efforts to collect uniformly assessed, large, well-powered samples and hypothesis-free genome-wide strategies. To further support startle as an endophenotype for anxiety, this review suggests advanced genetic strategies for startle research.

Keyphrases

genome wide
dna methylation
endothelial cells
sleep quality
mental health
gene expression
depressive symptoms
pluripotent stem cells