Longitudinal monitoring of STAT3 phosphorylation and histologic outcome of tofacitinib therapy in patients with ulcerative colitis.

Bram VerstocktValery VolkCharlot JaeckelDahham AlsoudJoão SabinoSusanna NikolausMarc FerranteNicole KrönkeFriedrich FeuerhakeGert De HertoghPhilip RosenstielSéverine VermeireStefan SchreiberMarc FerranteKonrad Aden

Published in: Alimentary pharmacology & therapeutics (2022)

Tofacitinib can induce and maintain endoscopic and histologic remission in up to one-quarter of highly refractory UC patients. Longitudinal monitoring of nuclear pSTAT3 in mucosal tissue compartments reflects distinctive on-target effects, independently of long-term treatment outcomes.

Keyphrases

ulcerative colitis
end stage renal disease
rheumatoid arthritis
newly diagnosed
ejection fraction
cross sectional
chronic kidney disease
cell proliferation
ultrasound guided
peritoneal dialysis
disease activity
systemic lupus erythematosus
mesenchymal stem cells
smoking cessation
cell therapy