Deep gray matter volume loss drives disability worsening in multiple sclerosis.

E Ann YehFerran PradosWallace J BrownleeDaniel R AltmannCarmen TurM Jorge CardosoFloriana De AngelisSteven H van de PavertNiamh CawleyAntonio GiorgioM Laura StromilloMarco BattagliniSerena RuggieriClaudio GasperiniMassimo FilippiMaria A RoccaAlex RoviraJaume Sastre-GarrigaHugo VrenkenCyra E LeursJoep KillesteinLukas PirpamerChristian EnzingerSebastien OurselinClaudia A M Gandini Wheeler-KingshottDeclan ChardAlan J ThompsonDaniel C AlexanderFrederik BarkhofOlga Ciccarellinull null

Published in: Annals of neurology (2018)

This large, multicenter and longitudinal study shows that DGM volume loss drives disability accumulation in MS, and that temporal cortical GM shows accelerated atrophy in SPMS than RRMS. The difference in regional GM atrophy development between phenotypes needs to be taken into account when evaluating treatment effect of therapeutic interventions. Ann Neurol 2018;83:210-222.

Keyphrases

multiple sclerosis
white matter
physical activity
mass spectrometry
cross sectional
ms ms
double blind