Dimethyl fumarate modulates the Treg-Th17 cell axis in patients with psoriasis.

J Sulaimani D Cluxton Julianne Clowry Andreea Petrasca Oonagh Molloy B Moran C M Sweeney Anna Malara Nuala McNicholas C McGuigan Brian Kirby Jean M Fletcher

Published in: The British journal of dermatology (2020)

DMF enhanced the ratio of Treg cells to Th17 cells in patients with psoriasis, in patients with multiple sclerosis and in vitro. Furthermore, our data suggest that this is at least in part as a result of the differential effects of DMF on Treg cells compared with conventional T cells.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
oxidative stress
signaling pathway
big data
cell proliferation
bone marrow
electronic health record
mesenchymal stem cells
data analysis