Dimethyl fumarate modulates the Treg-Th17 cell axis in patients with psoriasis.
J SulaimaniD CluxtonJulianne ClowryAndreea PetrascaOonagh MolloyB MoranC M SweeneyAnna MalaraNuala McNicholasC McGuiganBrian KirbyJean M FletcherPublished in: The British journal of dermatology (2020)
DMF enhanced the ratio of Treg cells to Th17 cells in patients with psoriasis, in patients with multiple sclerosis and in vitro. Furthermore, our data suggest that this is at least in part as a result of the differential effects of DMF on Treg cells compared with conventional T cells.