This review summarises the data from long-term experimental studies and literature data on the role of oxidatively modified low-density lipoproteins (LDL) in atherogenesis and diabetogenesis. It was shown that not "oxidized" (lipoperoxide-containing) LDL, but dicarbonyl-modified LDL are atherogenic (actively captured by cultured macrophages with the help of scavenger receptors), and also cause expression of lectin like oxidized low density lipoprotein receptor 1 ( LOX-1 ) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 ( NOX-1 ) genes in endotheliocytes, which stimulate apoptosis and endothelial dysfunction. The obtained data allowed us to justify new approaches to pharmacotherapy of atherosclerosis and diabetes mellitus.
Keyphrases
- low density lipoprotein
- electronic health record
- big data
- systematic review
- poor prognosis
- oxidative stress
- cell death
- genome wide
- endoplasmic reticulum stress
- type diabetes
- dna methylation
- data analysis
- smoking cessation
- reactive oxygen species
- cell cycle arrest
- metabolic syndrome
- insulin resistance
- glycemic control
- signaling pathway
- bioinformatics analysis