Epigenomic dysregulation-mediated alterations of key biological pathways and tumor immune evasion are hallmarks of gingivo-buccal oral cancer.
Debodipta DasSahana GhoshArindam MaitraNidhan K BiswasChinmay K PandaBidyut RoyRajiv SarinPartha P MajumderPublished in: Clinical epigenetics (2019)
In OSCC-GB patients, there are significant alterations in expression of key genes that (a) regulate normal cell division by maintenance of balanced DNA methylation and transcription process, (b) maintain normal physiological signaling (PPAR, B cell receptor) and metabolism (arachidonic acid) pathways, and (c) provide immune protection against antigens, including tumor cells. These findings indicate novel therapeutic targets, including immunotherapeutic, for treatment of OSCC-GB.
Keyphrases
- dna methylation
- end stage renal disease
- genome wide
- newly diagnosed
- ejection fraction
- chronic kidney disease
- poor prognosis
- gene expression
- single cell
- peritoneal dialysis
- stem cells
- cell therapy
- insulin resistance
- transcription factor
- type diabetes
- binding protein
- metabolic syndrome
- dendritic cells
- mesenchymal stem cells
- copy number