Immunoregulatory Effects of the Active Form of Vitamin D (Calcitriol), Individually and in Combination with Curcumin, on Peripheral Blood Mononuclear Cells (PBMCs) of Multiple Sclerosis (MS) Patients.
Mahdieh FasihiMahsa Samimi-BadabiBehrouz Robat-JaziSama BitarafanAbdorreza Naser MoghadasiFatemeh MansouriMir Saeed YekaninejadMaryam IzadAli Akbar Saboor-YaraghiPublished in: Anti-inflammatory & anti-allergy agents in medicinal chemistry (2024)
This study demonstrates that curcumin and calcitriol can effectively modulate the inflammatory processes intrinsic to MS by mitigating the expression of inflammatory cytokines by Th1 and Th17 cells while concurrently enhancing the regulatory role of Treg cells. Moreover, the combined treatment of curcumin and calcitriol did not yield superior outcomes compared to single-dosing strategies.
Keyphrases
- multiple sclerosis
- induced apoptosis
- cell cycle arrest
- mass spectrometry
- end stage renal disease
- ms ms
- ejection fraction
- oxidative stress
- newly diagnosed
- poor prognosis
- chronic kidney disease
- endoplasmic reticulum stress
- type diabetes
- white matter
- prognostic factors
- signaling pathway
- adipose tissue
- metabolic syndrome
- skeletal muscle
- binding protein
- long non coding rna
- insulin resistance