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ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors.

Xin BiSylvia StankovPaul C LeeZiyi WangXun WuLi LiYi-An KoLan ChengHanrui ZhangNicholas J HandDaniel James Rader
Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Our results support ILRUN as an important novel regulator of atherogenesis that promotes lesion progression and necrosis. It influences atherosclerosis through both plasma lipid-dependent and lipid-independent mechanisms. These findings support ILRUN as the likely causal gene responsible for genetic association of variants with coronary artery disease at this locus and suggest that suppression of ILRUN activity might be expected to reduce atherosclerosis.
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