Regenerative potential of Wharton's jelly-derived mesenchymal stem cells: A new horizon of stem cell therapy.
Hossein AbbaszadehFarzaneh GhorbaniMehdi DerakhshaniAli Akbar MovassaghpourMehdi YousefiMehdi TalebiKarim ShamsasenjanPublished in: Journal of cellular physiology (2020)
Umbilical cord Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) have recently gained considerable attention in the field of regenerative medicine. Their high proliferation rate, differentiation ability into various cell lineages, easy collection procedure, immuno-privileged status, nontumorigenic properties along with minor ethical issues make them an ideal approach for tissue repair. Besides, the number of WJ-MSCs in the umbilical cord samples is high as compared to other sources. Because of these properties, WJ-MSCs have rapidly advanced into clinical trials for the treatment of a wide range of disorders. Therefore, this paper summarized the current preclinical and clinical studies performed to investigate the regenerative potential of WJ-MSCs in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
Keyphrases
- umbilical cord
- cell therapy
- mesenchymal stem cells
- clinical trial
- bone marrow
- stem cells
- soft tissue
- left ventricular
- skeletal muscle
- working memory
- human health
- bone mineral density
- randomized controlled trial
- minimally invasive
- heart failure
- drinking water
- single cell
- extracellular matrix
- replacement therapy
- combination therapy
- wound healing
- bone regeneration