Serum Krebs von den Lungen-6 and lung ultrasound B lines as potential diagnostic and prognostic factors for rheumatoid arthritis-associated interstitial lung disease.
Dina Salem FotohAsrar HelalMohamed S RizkHeba A EsailyPublished in: Clinical rheumatology (2021)
• Combination of the non-invasive, radiation-free LUS with a score < 5.5 and serum KL6 levels of 277.5 U/ml is recommended as prognostic tools for RA-ILD. • Easily obtainable tests such as serum KL-6, inflammatory markers, and LUS are sensitive for assessing RA-ILD and the risk of poor outcomes in patients with RA-ILD. • RA-ILD patients with higher KL6 levels, higher LUS scores had a poor prognosis with short survival. • LUS B lines could be used as the first imaging tool for the evaluation of RA-ILD decreasing the risk of HRCT radiation exposure in asymptomatic or mild RA-ILD patients.
Keyphrases
- interstitial lung disease
- rheumatoid arthritis
- systemic sclerosis
- prognostic factors
- poor prognosis
- disease activity
- idiopathic pulmonary fibrosis
- ankylosing spondylitis
- long non coding rna
- end stage renal disease
- magnetic resonance imaging
- radiation therapy
- high resolution
- newly diagnosed
- peritoneal dialysis
- type diabetes
- risk assessment
- patient reported outcomes