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Characterization and genome-informatic analysis of a novel lytic mendocina phage vB_PmeS_STP12 suitable for phage therapy pseudomonas or biocontrol.

Sani Sharif UsmanEvangeline Christina
Published in: Molecular biology reports (2024)
Taken together, characterization, morphological analysis and genome-informatics indicated that vB_PmeS_STP12 is podovirus morphotype belonging to the class Caudoviticetes, family Zobellviridae which appeared to be devoid of integrase gene, ARGs, CRISPR arrays, virulence factors and toxins genes, exhibiting stability and infectivity at wide range of pH (4 to10) and temperature (-20 to 70 °C), thereby making vB_PmeS_STP12 suitable for phage therapy or biocontrol. Based on the bibliometric analysis and data availability with respect to sequences deposited in GenBank, this is the first report of a phage infecting Pseudomonas mendocina.
Keyphrases
  • pseudomonas aeruginosa
  • genome wide
  • biofilm formation
  • cystic fibrosis
  • dna methylation
  • staphylococcus aureus
  • crispr cas
  • big data
  • mesenchymal stem cells
  • genome editing
  • transcription factor
  • wastewater treatment