Stress responses of human retinal pigment epithelial cells to glyoxal.

Cora RoehleckeMonika ValtinkAnnika FrenzelDoris GoetzeLilla KnelsHenning MorawietzRichard H W Funk

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2016)

The glyoxal-induced oxidative stress and apoptosis in ARPE-19 cells may provide a suitable in vitro model for studying RPE cellular reactions to AGEs that occur in AMD or in DR.

Keyphrases

cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
endothelial cells
pi k akt
oxidative stress
pluripotent stem cells
signaling pathway
editorial comment
nitric oxide