NAIL: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitis.

Semih Can Akincilar Lele WuQin Feng NgJoelle Yi Heng ChuaBilal UnalTaichi NodaWei Hong Jeff ChorMasahito IkawaVinay Tergaonkar

Published in: Gut (2020)

NAIL directly regulates initiation and progression of colitis and its expression is highly correlated with NFκB activity which makes it a perfect candidate to serve as a biomarker and a therapeutic target for IBD and other inflammation-associated diseases.

Keyphrases

oxidative stress
signaling pathway
lps induced
ulcerative colitis
pi k akt
poor prognosis
nuclear factor
long non coding rna
transcription factor
long noncoding rna