NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization.

Sonali NarangNikki A EvensenJason SalibaJoanna PierroMignon L LohPatrick A BrownPandurang KolekarHeather MulderYing ShaoJohn EastonXiaotu MaAristotelis TsirigosWilliam L Carroll

Published in: Genome biology (2023)

In spite of cell-context-dependent changes mediated by EK, there appears to be a shared transcriptional program dependent on compartment shifts which could explain phenotypic differences across EK cell lines. This core program is an attractive target for therapeutic intervention.

Keyphrases

acute lymphoblastic leukemia
quality improvement
gene expression
transcription factor
randomized controlled trial
single cell
cell therapy
dna damage
allogeneic hematopoietic stem cell transplantation
dna methylation
genome wide