Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults.

Alexandra H BartlettJane W LiangJose Vladimir Sandoval-SierraJay H FowkeEleanor M SimonsickKaren C JohnsonKhyobeni Mozhui

Published in: Biomarker research (2019)

The results show that changes in cellular composition explains much of the cross-sectional and longitudinal variation in CpG methylation. Additionally, differential methylation and longitudinal dynamics at specific CpGs could provide powerful indicators of cancer development and/or progression. In particular, we highlight CpG methylation in the RPTOR gene as a potential biomarker of cancer that awaits further validation.

Keyphrases

dna methylation
genome wide
cross sectional
papillary thyroid
gene expression
copy number
squamous cell
physical activity
squamous cell carcinoma